Along with dietary intake, nutrition can also be obtained from nutrient supplements. They are widely used in the
general population and their market is growing. It has been assumed adequate intake of them contributes to better
overall mental health. This review explores studies regarding the role of different nutrients in treatment of
depression. After searching among them we found Testosterone, Omega 3 fatty acid, Thyroid hormones, Modafinil,
Folate, Vitamin B12, S-Adenosyl Methionine (SAMe), Magnesium, and Zinc as supplements which has some effect in
combination with anti-depressant medications. They have advantages and also some disadvantages. In this review
paper, we have taken a look at each of these agents individually and mentioned their current status in the treatment of depression.
Keywords: Depression; Supplement nutrient; Testosterone; Omega 3 fatty acid; Thyroid hormones; Modafinil;
Folate; Vitamin B12; SAMe; Magnesium; Zinc